3DCENTRAL aims at connecting “islands of innovation” to a stable network of regions for innovation. It is focused on smart engineering and rapid prototyping where a substantial, current and future emerging market for cooperation partners is visible. Generally there is a solid knowledge base in the programme area but it is little structured and connected. This leads to inefficiencies in developing regions as well as in the RTD and business sector. To tackle these challenges durable solutions with sufficient resources are required. The main objective of 3DCENTRAL is to develop, implement and anchor powerful, practicable, future robust knowledge axes for the central Europe (KACE) cooperation area to tighten and boost the linkages and capacities amongst the relevant technology and innovation actors of smart engineering and rapid prototyping. 3DCENTRAL will change the current situation by establishing replicable system of new strong structures (KACE), repeatable processes (CE Brain Base) and leading edge implementation cases (CE flagships). The main outputs are a transnational, action-oriented system for 11 knowledge axes, the toolbox and transnational tech&inno camps to make the change elements stable, and 11 flagship pilot demo cases.